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03 - Toxicokinetics and Toxicodynamics (Toxicology for Chemists - Module 3)

03 - Toxicokinetics and Toxicodynamics (Toxicology for Chemists - Module 3)
Contributors
Beyond Benign, Inc.
Assistant Professor, Environmental and Occupational Health | University of Pittsburgh, Pittsburgh Campus
toxicology for chemists curriculum orange cover with white text
Summary
This module is an introduction to toxicokinetics and toxicodynamics. The module is split into five lectures addressing: absorption, distribution, biotransformation, excretion, and toxicodynamics. Using these materials, students will be able to: explain and describe ADME; learn introductory biochemistry, chemistry, and anatomy to explain ADME; and explain and describe toxicodynamics. The lecture slides have multiple in-class discussions and assignments throughout.

What’s included?

Lectures:
-“3A – Absorption” (0.5-1 hour)
-“3B – Distribution” (0.5-1 hour)
-“3C – Biotransformation” (0.5-1 hour)
-“3D – Excretion” (0.5-1 hour)
-“3E – Toxicodynamics” (1-2 hours)

Lesson Plans:
For all lectures
Supplementary Information:
Two student assignments
Additional resources for instructors and students

File Size: 29 MB

This course module was authored by:
Nesta Bortey-Sam, PhD, Assistant Professor, University of Pittsburgh
Abdulrahman N. Alobireed, MPH, University of Pittsburgh

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Moderation state
Published
Object Type
Lecture or course slides/notes (e.g., PPT, Prezi, PDF)
Lesson summaries
Videos (e.g., tutorials, presentations)
Journal articles
Audience
Introductory Undergraduate
Upper/Advanced Undergraduate
Published on
Green Chemistry Principles
Less Hazardous Chemical Syntheses
Reduce Derivatives
Learning Goals/Student Objectives
After completing this lesson, you will be able to:

Define toxicokinetics
-Explain absorption and its role in toxicokinetics.
-Describe the primary routes of exposure.
-Summarize the four inter-related processes of toxicokinetics
-Identify examples of transporter proteins and their role in toxicokinetics
Time required (if applicable)
3.5-4 hours

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