11 - Structure-Activity Relationships (Toxicology for Chemists - Module 11)

This module connects the structure of molecules to their activity in biological systems. Students will be able to: identify physicochemical properties related to ADME; identify and rationalize relationships between physiochemical properties and biological activity in different species; apply pre-screening tools for acute and chronic human and ecological endpoints based on physicochemical properties; and identify potential toxicants. Particular emphasis is placed on carbon-based toxicants and this Module aligns very closely with Module 4 – Reaction Mechanisms in Toxicology and can act as a supporting resource. Multiple in-class assignments and case studies are contained in the lecture slides for students to complete during class lectures.

What’s included?

Lectures:
“11A – Structure, Physicochemical Properties, and Biological Activity” (2-3 hours)
“11B – Structure, Physicochemical Properties, and Biological Activity” (2-3 hours)
Supplementary Information: contained within the lecture slides and lesson plan, in addition to:
A glossary of terms
Supplemental data on flammability
A list of resources for instructors to refer to
File Size: 10 MB

This course module was authored by:
Dr. Adelina Voutchkova-Kostal, Associate Professor, The George Washington University
Dr. Diana Ainembabzi, Postdoctoral Fellow, Indiana University School of Medicine