A convenient guide to help select replacement solvents for dichloromethane in chromatography
Summary
This article overviews a study of the eluting properties of greener solvent systems as a replacement for dichloromethane in chromatography and chromatographic purification. A library of "drug-like" compounds was used to determine the efficacy and potential application of the greener solvent systems for purification. In particular, various mixtures of 3:1 EtOAc:EtOH in hexanes were found to have wide applicability for acidic, basic and neutral analytes. More details are available in the linked article.
Full citation: Taygerly, J. P.; Miller, L. M.; Yee, A.; Peterson, E. A. A Convenient Guide to Help Select Replacement Solvents for Dichloromethane in Chromatography. Green Chem. 2012, 14 (11), 3020. https://doi.org/10.1039/c2gc36064k.
Full citation: Taygerly, J. P.; Miller, L. M.; Yee, A.; Peterson, E. A. A Convenient Guide to Help Select Replacement Solvents for Dichloromethane in Chromatography. Green Chem. 2012, 14 (11), 3020. https://doi.org/10.1039/c2gc36064k.
Safety Precautions, Hazards, and Risk Assessment
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