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04 - Reaction Mechanisms (Toxicology for Chemists - Module 4)

04 - Reaction Mechanisms (Toxicology for Chemists - Module 4)
Contributors
Beyond Benign, Inc.
Professor Emeritus | South Dakota State University
toxicology for chemists curriculum orange cover with white text
Summary
This module gives an overview of the main reaction mechanisms seen in toxicology studies. Students will learn primarily about the main electrophilic reactions that bind toxicants to proteins, in addition to a brief introduction to reactive oxygen species and radical reactions. This module pairs well with Module 11 – Structure-Activity Relationships, and these lecture slides are also included for your convenience! Finally, the full deck of ChemToxTidbits (one-slide case studies on specific organic chemistry reactions and their relationship to toxicology) are included.

What’s included?

Lectures:
“4AB – Reaction Mechanisms in Toxicology” (1-2 hours)
“11A – Structure-Activity Relationships” (1-2 hours)
“11B – Structure-Activity Relationships” (1-2 hours)
“ChemToxTidbits Slides” (to be used individually)
Supplementary Information:
Two student assignments.


File Size: 19 MB

This course module was authored by:
Dr. Douglas Raynie, Associate Professor, South Dakota State University

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Moderation state
Published
Object Type
Lecture or course slides/notes (e.g., PPT, Prezi, PDF)
Activities/Technology (e.g., in-class activities, online games, hands-on activities/manipulatives, outreach, virtual tools, etc.)
Audience
Introductory Undergraduate
Upper/Advanced Undergraduate
Published on
Green Chemistry Principles
Less Hazardous Chemical Syntheses
Designing Safer Chemicals
NGSS Standards, if applicable
N/A
Learning Goals/Student Objectives
Why do we study these reactions in toxicology?

-To report information on a number of toxic effects brought about by reaction mechanisms:
--Formation of covalent bonds between a reactive, electron-poor (electrophilic) substrate and a biological electron-rich (nucleophilic) target molecule (especially nucleic acids and proteins

-To build adequate models for end-points and effects related to reactive mechanisms of toxic action!
--For electrophile-nucleophile covalent interactions, information is required on the likelihood and rate of reaction of a chemical with a particular biological nucleophile.
Common pedagogies covered
Collaborative/cooperative learning
Computer-based learning
Time required (if applicable)
2-3 hours

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