Octanol–Water Partition Coefficient Measurement by a Simple 1H NMR Method
Summary
This article describes a simple approach for measuring the octanol-water partition coefficient (Kow) of organic compounds using a simple miniature variation of the shake-flask method in an NMR tube, which can be quickly analyzed using a benchtop 1H NMR spectrometer. The article also details the scope and limitations of the method. Kow is an important metric for understanding bioaccumulation and toxicity of compounds in living organisms and in the environment.
Full citation: Cumming, H.; Rücker, C. Octanol–Water Partition Coefficient Measurement by a Simple 1 H NMR Method. ACS Omega 2017, 2 (9), 6244–6249. https://doi.org/10.1021/acsomega.7b01102.
Full citation: Cumming, H.; Rücker, C. Octanol–Water Partition Coefficient Measurement by a Simple 1 H NMR Method. ACS Omega 2017, 2 (9), 6244–6249. https://doi.org/10.1021/acsomega.7b01102.
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