Green Chemistry and Peptide Synthesis: Comparing Solid Phase Peptide Synthesis and Protease-Catalyzed Peptide Synthesis

This case study explores Protease Catalyzed Peptide Synthesis (PCPS) as an example of a synthetic strategy that aligns with the 12 principles of Green Chemistry, however, struggles to be a viable strategy for large scale peptide synthesis. In comparison, Solid Phase Peptide Synthesis (SPPS) remains the primary method of chemical peptide synthesis despite the significant amounts of chemical waste generated using this strategy.