Markers of Excellence (Level 3) - ACS Guidelines

This module provides an overview of computational methods to predict the toxicity of chemicals. Students will learn an updated overview of the latest methods that have been successfully applied to predict toxic effects of chemicals, in addition to understanding the outlook towards at the nexus of computational sciences and toxicology. Particular emphasis is placed on carbon-based toxicants ...

This module connects the structure of molecules to their activity in biological systems. Students will be able to: identify physicochemical properties related to ADME; identify and rationalize relationships between physiochemical properties and biological activity in different species; apply pre-screening tools for acute and chronic human and ecological endpoints based on physicochemical ...

Don’t have much time to prepare your lectures? Don’t know where to start with incorporating toxicology into existing class lectures or assignments? Not sure if you’re ready to adopt a full module? Do you just want access to the case studies, in-class assignments, homework assignments, and ChemToxTidbits slides? This folder contains all of these materials in a format easily accessible to you so ...

This is a poster of the 12 Principles of Green Chemistry. The poster can be printed out in varying sizes and is designed to be used as a teaching tool in a classroom, laboratory or manufacturing setting.

Please select the file below based on your audience location. For those in North America please use the MilliporeSigma file, for those outside North America please use the international Merck ...

This article overviews a study of the eluting properties of greener solvent systems as a replacement for dichloromethane in chromatography and chromatographic purification. A library of "drug-like" compounds was used to determine the efficacy and potential application of the greener solvent systems for purification. In particular, various mixtures of 3:1 EtOAc:EtOH in hexanes were found to have ...

The alkylation of aromatic compounds is a very important industrial process. Typically these alkylations are performed using strong Lewis acids like aluminum trichloride as catalysts. However, the use of these catalysts often requires an aqueous work-up to remove the aluminum and also leads to mixtures of products due to carbocation rearrangement.

By using graphite this greener alkylation ...

Citronellal is a naturally occurring aldehyde derived from essential oils like citronella. In this laboratory activity, citronellal undergoes a cyclization reaction to form isopulegol, a chiral terpene with various applications. The reaction utilizes montmorillonite (MK10) clay as a catalyst in a buffer medium at room temperature for 2 hours. NMR Spectroscopy is used to characterize the product. ...

This laboratory activity focuses on the tie-dyeing process as a safer alternative to nucleophilic aromatic substitution (SNAr) reactions for an introductory organic chemistry laboratory. The simple and straightforward experiment provides students with an opportunity to gain practical experience in conducting a chemical reaction in a real-world context while applying concepts of design for ...

This exercise demonstrates the regioselectivity of substituted aromatic systems while reducing the amount and hazards of the waste produced by the class. Although typical iodinations involve either high amounts of derivatization (i.e., nitration, then reduction to aniline, formation of diazonium, then ionization) or use of hazardous/expensive reagents (iodine and mercury acetate, bis(pyridine ...

This experiment teaches students the concept of colligative properties using renewable, benign, and biodegradable materials. Rather than using conventional solvents with high cryoscopic constants (which are oftentimes aromatics), fatty acids are used to explore freezing-point depression. By monitoring the change in freezing points of solutions with varying solute concentrations, students will be ...